The Cabrele Research Group

organic chemistry for protein research

Proteins are key players in all cellular processes and their correct (normal) function is prerequisite for a healthy life. The umpteen roles of proteins include the activation of DNA transcription, the transport of messenger RNA from the nucleus to the cytoplasm, the biocatalysis of reactions (which otherwise would be too slow and fully unspecific), the regulation of signaling cascades. Once one or more proteins start to behave abnormally, uncontrolled events occur in the cells, which dramatically raises the risk of developing pathologies. The deep understanding of the mode of action of proteins under healthy and pathological conditions is necessary for the development of modern and efficient strategies in the diagnosis and therapy of diseases. Organic and bioorganic chemistry largely contributes to this “mission” by reproducing, mimicking and manipulating target biomolecules as well as by providing artificial modulators of their function.