Transcutaneous immunotherapy via laser‐generated micropores efficiently alleviates allergic asthma in Phl p 5 – sensitized mice
D. Bach, R. Weiss, M. Hessenberger, S. Kitzmueller, E. E. Weinberger, W. D. Krautgartner, C. Hauser‐Kronberger, C. Boehler, J. Thalhamer1 & S. Scheiblhofer

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Transcutaneous vaccination via laser microporation
Richard Weiss, Michael Hessenberger, Sophie Kitzmüller, Doris Bach, Esther E. Weinberger, Wolf D. Krautgartner, Cornelia Hauser‐Kronberger, Bernard Malissen, Christof Boehler, Yogeshvar N. Kalia, Josef Thalhamer, Sandra Scheiblhofer

Abstract
Approaches for innovative treatment of type I allergies aim at increased efficacy to shorten schedules and at increased safety by avoiding contact of the allergen with the general circulation. The skin represents a promising target tissue, which is easily accessible, rich in antigen presenting cells, and non‐vascularized at its superficial layers. In two publications, Richard Weiss and Doris Bach introduced laser‐based microporation for transcutaneous application of vaccines and demonstrated its efficacy for allergen‐specific immunotherapy in a mouse model of allergic asthma.

The open access articles can be found at
 http://onlinelibrary.wiley.com/doi/10.1111/all.12005/full and  http://www.sciencedirect.com/science/article/pii/S0168365912005317

Reviewed by Johann Brandstetter