„Rational Design, Structure–Activity Relationship, and Immunogenicity of Hypoallergenic Pru p 3 Variants“
Stephanie Eichhorn, Angelika Hörschläger, Markus Steiner, Josef Laimer,Bettina M Jensen, Serge A Versteeg, Isabel Pablos, Peter Briza, Laurian Jongejan,Neil Rigby, Juan A Asturias, Antonio Portol´es, Montserrat Fernandez-Rivas,Nikolaos G Papadopoulos, Adriano Mari, Lars K Poulsen, Peter Lackner, Ronald van Ree, Fatima Ferreira and Gabriele Gadermaier
Abstract: 
Severe allergic reactions to peaches are triggered by the non-specific lipid transfer protein (LTP) Pru p 3. Within the EU-funded project FAST, we designed hypoallergenic variants of Pru p 3 for treatment of LTP-related food allergies. One of the candidate molecules (Pru p 3 proline variant) proved to be strongly hypoallergenic when using patients’ sera in ELISA and mediator release assays. In contrast to previously generated Pru p 3 mutants, our molecule remained structurally stable and immunogenic thus representing a promising candidate for peach allergen immunotherapy.

The open access article can be found  here.
Reviewed by Ursula Lütz-Meindl.

CONGRATULATIONS!