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J Allergy Clin Immunol 142(3), 984–987.e6 (2018)
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Harmonization of the Genetic Code Effectively Enhances the Recombinant Production of the Major Birch Pollen Allergen Bet v 1
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The cytokine network in acute myeloid leukemia (AML): A focus on pro- and anti-inflammatory mediators
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Dall E, Hollerweger JC, Dahms SO, Cui H, Häussermann K, Brandstetter H
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Durand-Onayli V, Haslauer T, Härzschel A, Hartmann T
Rac GTPases in Hematological Malignancies
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Biologic effects of nanoparticle-allergen conjugates: time-resolved uptake using an in vitro lung epithelial co-culture model of A549 and THP-1 cells
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Guo S, Briza P, Magdolen V, Brandstetter H, Goettig P
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Top-down and bottom-up characterization of nitrated birch pollen allergen Bet v 1a with CZE hyphenated to an Orbitrap mass spectrometer
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Microenvironment-induced CD44v6 promotes early disease progression in chronic lymphocytic leukemia
Blood 131(12), 1337–1349 (2018)
Hollerweger JC, Hoppe IJ, Regl C, Stock LG, Huber CG, Lohrig U, Stutz H, Brandstetter H
Analytical Cascades of Enzymes for Sensitive Detection of Structural Variations in Protein Samples
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Klicznik MM, Benedetti A, Stoecklinger A, Campbell DJ, Gratz IK
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Taking the lead – how keratinocytes orchestrate skin T cell immunity
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Schubert M, Greil R, Geisberger R
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Investigating epigenetic effects of activation-induced deaminase in chronic lymphocytic leukemia
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STAT3 promotes melanoma metastasis by CEBP-induced repression of the MITF pigmentation pathway
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Opioids trigger breast cancer metastasis through E-Cadherin downregulation and STAT3 activation promoting epithelial-mesenchymal transition
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Exome sequencing of the TCL1 mouse model for CLL reveals genetic heterogeneity and dynamics during disease development
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Zauner FB, Dall E, Regl C, Grassi L, Huber CG, Cabrele C, Brandstetter H
Crystal Structure of Plant Legumain Reveals a Unique Two-Chain State with pH-Dependent Activity Regulation
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Structural analyses of Arabidopsis thaliana legumain γ reveal differential recognition and processing of proteolysis and ligation substrates
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Acute myeloid leukemia – strategies and challenges for targeting oncogenic Hedgehog/GLI signaling
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Synthesis and biological evaluation of potential inhibitors of the cysteine proteases cruzain and rhodesain designed by molecular simplification
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Distinct Roles of Catalytic Cysteine and Histidine in the Protease and Ligase Mechanisms of Human Legumain As Revealed by DFT-Based QM/MM Simulations
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Gassner FJ, Schubert M, Rebhandl S, Spandl K, Zaborsky N, Catakovic K, Blaimer S, Hebenstreit D, Greil R, Geisberger R
Imprecision and DNA Break Repair Biased towards Incompatible End Joining in Leukemia
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Understanding cell signaling in cancer stem cells for targeted therapy – can phosphoproteomics help to reveal the secrets?
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Nanomaterials in the Context of Type 2 Immune Responses – Fears and Potentials
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Expression and Characterization of Functional Recombinant Bet v 1.0101 in the Chloroplast of Chlamydomonas reinhardtii
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Bacterial endotoxin (lipopolysaccharide) binds to the surface of gold nanoparticles, interferes with biocorona formation and induces human monocyte inflammatory activation
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Multi-Approach Analysis for the Identification of Proteases within Birch Pollen
Int J Mol Sci 18(7), 1433 (2017)
Neuper T, Ellwanger K, Schwarz H, Kufer TA, Duschl A, Horejs-Hoeck J
NOD1 modulates IL-10 signalling in human dendritic cells
Sci Rep 7(1), (2017)
Pablos I, Eichhorn S, Briza P, Asam C, Gartner U, Wolf M, Ebner C, Bohle B, Arora N, Vieths S, Ferreira F, Gadermaier G
Proteomic profiling of the weed feverfew, a neglected pollen allergen source
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Allergy 73(2), 431–441 (2017)
Sancho AI, Wallner M, Hauser M, Nagl B, Himly M, Asam C, Ebner C, Jahn-Schmid B, Bohle B, Ferreira F
T Cell Epitope-Containing Domains of Ragweed Amb a 1 and Mugwort Art v 6 Modulate Immunologic Responses in Humans and Mice
PLoS One 12(1), e0169784 (2017)
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Influence of protein fold stability on immunogenicity and its implications for vaccine design
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Sci Rep 7(1), (2017)
Schönauer E, Kany AM, Haupenthal J, Hüsecken K, Hoppe IJ, Voos K, Yahiaoui S, Elsässer B, Ducho C, Brandstetter H, Hartmann RW
Discovery of a Potent Inhibitor Class with High Selectivity toward Clostridial Collagenases
J Am Chem Soc 139(36), 12696–12703 (2017)
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Conjugation of wildtype and hypoallergenic mugwort allergen Art v 1 to flagellin induces IL-10-DC and suppresses allergen-specific TH2-responses in vivo
Sci Rep 7(1), (2017)
Silva ESd, Asam C, Lackner P, Hofer H, Wallner M, Pinheiro CS, Alc{\^{a}}ntara-Neves NM, Ferreira F
Allergens of Blomia tropicalis: An Overview of Recombinant Molecules
Int Arch Allergy Immunol 172(4), 203–214 (2017)
Soh W, Briza P, Dall E, Asam C, Schubert M, Huber S, Aglas L, Bohle B, Ferreira F, Brandstetter H
Two Distinct Conformations in Bet v 2 Determine Its Proteolytic Resistance to Cathepsin S
Int J Mol Sci 18(10), 2156 (2017)
Stemeseder T, Freier R, Wildner S, Fuchs JE, Briza P, Lang R, Batanero E, Lidholm J, Liedl KR, Campo P, Hawranek T, Villalba M, Brandstetter H, Ferreira F, Gadermaier G
Crystal structure of Pla l 1 reveals both structural similarity and allergenic divergence within the Ole e 1-like protein family
J Allergy Clin Immunol 140(1), 277–280 (2017)
Strandt H, Pinheiro DF, Kaplan DH, Wirth D, Gratz IK, Hammerl P, Thalhamer J, Stoecklinger A
Neoantigen Expression in Steady-State Langerhans Cells Induces CTL Tolerance
J Immunol 199(5), 1626–1634 (2017)
Strasser L, Dang H-, Schwarz H, Asam C, Ferreira F, Horejs-Hoeck J, Huber CG
Unbiased Quantitative Proteomics Reveals a Crucial Role of the Allergen Context for the Activation of Human Dendritic Cells
Sci Rep 7(1), (2017)
Wessler S, Aberger F, Hartmann TN
The sound of tumor cell-microenvironment communication – composed by the Cancer Cluster Salzburg research network
Cell Commun Signal 15(1), (2017)
Wessler S, Krisch LM, Elmer DP, Aberger F
From inflammation to gastric cancer – the importance of Hedgehog/GLI signaling in Helicobacter pylori-induced chronic inflammatory and neoplastic diseases
Cell Commun Signal 15(1), (2017)
Wessler S, Schneider G, Backert S
Bacterial serine protease HtrA as a promising new target for antimicrobial therapy?
Cell Commun Signal 15(1), (2017)
Wildner S, Elsässer B, Stemeseder T, Briza P, Soh WT, Villalba M, Lidholm J, Brandstetter H, Gadermaier G
Endolysosomal Degradation of Allergenic Ole e 1-Like Proteins: Analysis of Proteolytic Cleavage Sites Revealing T Cell Epitope-Containing Peptides
Int J Mol Sci 18(8), 1780 (2017)
Wolf M, Twaroch TE, Huber S, Reithofer M, Steiner M, Aglas L, Hauser M, Aloisi I, Asam C, Hofer H, Parigiani MA, Ebner C, Bohle B, Briza P, Neubauer A, Stolz F, Jahn-Schmid B, Wallner M, Ferreira F
Amb a 1 isoforms: Unequal siblings with distinct immunological features
Allergy 72(12), 1874–1882 (2017)
2016
Abfalter CM, Schönauer E, Ponnuraj K, Huemer M, Gadermaier G, Regl C, Briza P, Ferreira F, Huber CG, Brandstetter H, Posselt G, Wessler S
Cloning, Purification and Characterization of the Collagenase ColA Expressed by Bacillus cereus ATCC 14579
PLoS One 11(9), e0162433 (2016)
Bacher P, Heinrich F, Stervbo U, Nienen M, Vahldieck M, Iwert C, Vogt K, Kollet J, Babel N, Sawitzki B, Schwarz C, Bereswill S, Heimesaat MM, Heine G, Gadermaier G, Asam C, Assenmacher M, Kniemeyer O, Brakhage AA, Ferreira F, Wallner M, Worm M, Scheffold A
Regulatory T Cell Specificity Directs Tolerance versus Allergy against Aeroantigens in Humans
Cell 167(4), 1067–1078.e16 (2016)
Gruber W, Hutzinger M, Elmer DP, Parigger T, Sternberg C, Cegielkowski L, Zaja M, Leban J, Michel S, Hamm S, Vitt D, Aberger F
DYRK1B as therapeutic target in Hedgehog/GLI-dependent cancer cells with Smoothened inhibitor resistance
Oncotarget 7(6), 7134–7148 (2016)
Haerzschel A, Catusse J, Hutterer E, Paunovic M, Zirlik K, Eibel H, Krenn PW, Hartmann TN, Burger M
BCR and chemokine responses upon anti-IgM and anti-IgD stimulation in chronic lymphocytic leukaemia
Ann Hematol 95(12), 1979–1988 (2016)
Krenn PW, Hofbauer SW, Pucher S, Hutterer E, Hinterseer E, Denk U, Asslaber D, Ganghammer S, Sternberg C, Neureiter D, Aberger F, Wickström SA, Egle A, Greil R, Hartmann TN
ILK Induction in Lymphoid Organs by a TNFα-NF-κB-Regulated Pathway Promotes the Development of Chronic Lymphocytic Leukemia
Cancer Res 76(8), 2186–2196 (2016)
Krisch LM, Posselt G, Hammerl P, Wessler S
CagA Phosphorylation in Helicobacter pylori-Infected B Cells Is Mediated by the Nonreceptor Tyrosine Kinases of the Src and Abl Families
Infect Immun 84(9), 2671–2680 (2016)
Machado Y, Freier R, Scheiblhofer S, Thalhamer T, Mayr M, Briza P, Grutsch S, Ahammer L, Fuchs JE, Wallnoefer HG, Isakovic A, Kohlbauer V, Hinterholzer A, Steiner M, Danzer M, Horejs-Hoeck J, Ferreira F, Liedl KR, Tollinger M, Lackner P, Johnson CM, Brandstetter H, Thalhamer J, Weiss R
Fold stability during endolysosomal acidification is a key factor for allergenicity and immunogenicity of the major birch pollen allergen
J Allergy Clin Immunol 137(5), 1525–1534 (2016)
McKenna OE, Asam C, Araujo GR, Roulias A, Goulart LR, Ferreira F
How relevant is panallergen sensitization in the development of allergies?
Pediatr Allergy Immunol 27(6), 560–568 (2016)
Pablos I, Wildner S, Asam C, Wallner M, Gadermaier G
Pollen Allergens for Molecular Diagnosis
Curr Allergy Asthma Rep 16(4), (2016)
Piret J, Bondarenko OM, Boyles MSP, Himly M, Ribeiro AR, Benetti F, Smal C, Lima B, Potthoff A, Simion M, Dumortier E, Leite PEC, Balottin LB, Granjeiro JM, Ivask A, Kahru A, Radauer-Preiml I, Tischler U, Duschl A, Saout C, Anguissola S, Haase A, Jacobs A, Nelissen I, Misra SK, Toussaint O
Pan-European inter-laboratory studies on a panel of in vitro cytotoxicity and pro-inflammation assays for nanoparticles
Arch Toxicol 91(6), 2315–2330 (2016)
Scheiblhofer S, Machado Y, Feinle A, Thalhamer J, Hüsing N, Weiss R
Potential of nanoparticles for allergen-specific immunotherapy {\textendash} use of silica nanoparticles as vaccination platform
Expert Opin Drug Deliv 13(12), 1777–1788 (2016)
Shatirishvili M, Burk AS, Franz CM, Pace G, Kastilan T, Breuhahn K, Hinterseer E, Dierich A, Bakiri L, Wagner EF, Ponta H, Hartmann TN, Tanaka M, Orian-Rousseau V
Epidermal-specific deletion of CD44 reveals a function in keratinocytes in response to mechanical stress
Cell Death Dis 7(11), e2461–e2461 (2016)
Zulehner N, Nagl B, Briza P, Roulias A, Ballmer-Weber B, Zlabinger GJ, Ferreira F, Bohle B
Characterization of the T-cell response to Dau c 1, the Bet v 1-homolog in carrot
Allergy 72(2), 244–251 (2016)
2015
Dall E, Fegg JC, Briza P, Brandstetter H
Structure and Mechanism of an Aspartimide-Dependent Peptide Ligase in Human Legumain
Angew Chem Int Ed 54(10), 2917–2921 (2015)
Diesner SC, Schultz C, Ackaert C, Oostingh GJ, Ondracek A, Stremnitzer C, Singer J, Heiden D, Roth-Walter F, Fazekas J, Assmann VE, Jensen-Jarolim E, Stutz H, Duschl A, Untersmayr E
Nitration of β-Lactoglobulin but Not of Ovomucoid Enhances Anaphylactic Responses in Food Allergic Mice
PLoS One 10(5), e0126279 (2015)
Freier R, Dall E, Brandstetter H
Protease recognition sites in Bet v 1a are cryptic, explaining its slow processing relevant to its allergenicity
Sci Rep 5(1), (2015)
Ganghammer S, Gutjahr J, Hutterer E, Krenn PW, Pucher S, Zelle-Rieser C, Johrer K, Wijtmans M, Leurs R, Smit MJ, Gattei V, Greil R, Hartmann TN
Combined CXCR3/CXCR4 measurements are of high prognostic value in chronic lymphocytic leukemia due to negative co-operativity of the receptors
Haematologica 101(3), e99–e102 (2015)
Ganghammer S, Hutterer E, Hinterseer E, Brachtl G, Asslaber D, Krenn PW, Girbl T, Berghammer P, Geisberger R, Egle A, Zucchetto A, Kruschinski A, Gattei V, Chigaev A, Greil R, Hartmann TN
CXCL12-induced VLA-4 activation is impaired in trisomy 12 chronic lymphocytic leukemia cells: a role for CCL21
Oncotarget 6(14), 12048–12060 (2015)
Grabner B, Schramek D, Mueller KM, Moll HP, Svinka J, Hoffmann T, Bauer E, Blaas L, Hruschka N, Zboray K, Stiedl P, Nivarthi H, Bogner E, Gruber W, Mohr T, Zwick RH, Kenner L, Poli V, Aberger F, Stoiber D, Egger G, Esterbauer H, Zuber J, Moriggl R, Eferl R, Gy{\H{o}}rffy B, Penninger JM, Popper H, Casanova E
Disruption of STAT3 signalling promotes KRAS-induced lung tumorigenesis
Nat Commun 6(1), (2015)
Guo S, Skala W, Magdolen V, Briza P, Biniossek ML, Schilling O, Kellermann J, Brandstetter H, Goettig P
A Single Glycan at the 99-Loop of Human Kallikrein-related Peptidase 2 Regulates Activation and Enzymatic Activity
J Biol Chem 291(2), 593–604 (2015)
Gutjahr JC, Greil R, Hartmann TN
The Role of CD44 in the Pathophysiology of Chronic Lymphocytic Leukemia
Front Immunol 6, (2015)
Hattinger E, Scheiblhofer S, Roesler E, Thalhamer T, Thalhamer J, Weiss R
Prophylactic mRNA Vaccination against Allergy Confers Long-Term Memory Responses and Persistent Protection in Mice
J Immunol Res 2015, 1–12 (2015)
Hinterseer E, Stiefel O, Neureiter D, Kandler G, Vogt S, Hutter J, Strasser G, Greil R, Hartmann TN, Hopfinger G
VLA-4 and CXCR4 overexpression in bone marrow of an aleukemic B-cell acute lymphoblastic leukemia presenting with osteolytic bone lesions
Leukemia Lymphoma 56(8), 2465–2467 (2015)
Kern D, Regl G, Hofbauer SW, Altenhofer P, Achatz G, Dlugosz A, Schnidar H, Greil R, Hartmann TN, Aberger F
Hedgehog/GLI and PI3K signaling in the initiation and maintenance of chronic lymphocytic leukemia
Oncogene 34(42), 5341–5351 (2015)
Kitzmüller C, Zulehner N, Roulias A, Briza P, Ferreira F, Fa{\'{e}} I, Fischer GF, Bohle B
Correlation of sensitizing capacity and T-cell recognition within the Bet v 1 family
J Allergy Clin Immunol 136(1), 151–158 (2015)
Maier E, Mittermeir M, Ess S, Neuper T, Schmiedlechner A, Duschl A, Horejs-Hoeck J
Prerequisites for Functional Interleukin 31 Signaling and Its Feedback Regulation by Suppressor of Cytokine Signaling 3 (SOCS3)
J Biol Chem 290(41), 24747–24759 (2015)
Moraes AH, Asam C, Batista A, Almeida FCL, Wallner M, Ferreira F, Valente AP
1H, 13C and 15N resonance assignments and second structure information of Fag s 1: Fagales allergen from Fagus sylvatica
Biomol NMR Assignm 10(1), 45–48 (2015)
Radauer-Preiml I, Andosch A, Hawranek T, Luetz-Meindl U, Wiederstein M, Horejs-Hoeck J, Himly M, Boyles M, Duschl A
Nanoparticle-allergen interactions mediate human allergic responses: protein corona characterization and cellular responses
Part Fibre Toxicol 13(1), (2015)
Weber CS, Hainz K, Deressa T, Strandt H, Pinheiro DF, Mittermair R, Pesado JP, Thalhamer J, Hammerl P, Stoecklinger A
Immune Reactions against Gene Gun Vaccines Are Differentially Modulated by Distinct Dendritic Cell Subsets in the Skin
PLoS One 10(6), e0128722 (2015)
Wolkerstorfer S, Schwaiger E, Rinnerthaler M, Gratz IK, Zoegg T, Brandstetter H, Achatz-Straussberger G
HAX1 deletion impairs BCR internalization and leads to delayed BCR-mediated apoptosis
Cell Mol Immunol 13(4), 451–461 (2015)
2014
Ackaert C, Kofler S, Horejs-Hoeck J, Zulehner N, Asam C, Grafenstein Sv, Fuchs JE, Briza P, Liedl KR, Bohle B, Ferreira F, Brandstetter H, Oostingh GJ, Duschl A
The Impact of Nitration on the Structure and Immunogenicity of the Major Birch Pollen Allergen Bet v 1.0101
PLoS One 9(8), e104520 (2014)
Asam C, Batista AL, Moraes AH, Paula VS, Almeida FCL, Aglas L, Kitzmüller C, Bohle B, Ebner C, Ferreira F, Wallner M, Valente AP
Bet v 1 – A Trojan horse for small ligands boosting allergic sensitization?
Clin Exp Allergy 44(8), 1083–1093 (2014)
Deressa T, Stoecklinger A, Wallner M, Himly M, Kofler S, Hainz K, Brandstetter H, Thalhamer J, Hammerl P
Structural Integrity of the Antigen Is a Determinant for the Induction of T-Helper Type-1 Immunity in Mice by Gene Gun Vaccines against E.coli Beta-Galactosidase
PLoS One 9(7), e102280 (2014)
Eibl C, Hessenberger M, Wenger J, Brandstetter H
Structures of the NLRP14 pyrin domain reveal a conformational switch mechanism regulating its molecular interactions
Acta Crystallogr D Biol Crystallogr 70(7), 2007–2018 (2014)
Ferreira F, Wolf M, Wallner M
Molecular Approach to Allergy Diagnosis and Therapy
Yonsei Med J 55(4), 839 (2014)
Gadermaier G, Eichhorn S, Vejvar E, Weilnböck L, Lang R, Briza P, Huber CG, Ferreira F, Hawranek T
Plantago lanceolata: An important trigger of~summer pollinosis with limited IgE cross-reactivity
J Allergy Clin Immunol 134(2), 472–475.e5 (2014)
Girbl T, Lunzer V, Greil R, Namberger K, Hartmann TN
The CXCR4 and adhesion molecule expression of CD34+ hematopoietic cells mobilized by „on-demand“ addition of plerixafor to granulocyte-colony-stimulating factor
Transfusion (Paris) 54(9), 2325–2335 (2014)
Grutsch S, Fuchs JE, Freier R, Kofler S, Bibi M, Asam C, Wallner M, Ferreira F, Brandstetter H, Liedl KR, Tollinger M
Ligand Binding Modulates the Structural Dynamics and Compactness of the Major Birch Pollen Allergen
Biophys J 107(12), 2972–2981 (2014)
Guo S, Skala W, Magdolen V, Brandstetter H, Goettig P
Sweetened kallikrein-related peptidases (KLKs): glycan trees as potential regulators of activation and activity
Biol Chem 395(9), 959–976 (2014)
Hutterer E, Asslaber D, Caldana C, Krenn PW, Zucchetto A, Gattei V, Greil R, Hartmann TN
CD18 (ITGB2) expression in chronic lymphocytic leukaemia is regulated by DNA methylation-dependent and -independent mechanisms
Br J Haematol 169(2), 286–289 (2014)
Isakovic A, Weiss R, Thalhamer J, Scheiblhofer S
Protective and Therapeutic DNA Vaccination Against Allergic Diseases
in: Methods Mol Biol, Springer New York (2014), 243–258
Muth T, Weilnböck L, Rapp E, Huber CG, Martens L, Vaudel M, Barsnes H
DeNovoGUI: An Open Source Graphical User Interface for de Novo Sequencing of Tandem Mass Spectra
J Proteome Res 13(2), 1143–1146 (2014)
Putz E, Hoelzl M, Baeck J, Bago-Horvath Z, Schuster C, Reichholf B, Kern D, Aberger F, Sexl V, Hoelbl-Kovacic A
Loss of STAT3 in Lymphoma Relaxes NK Cell-Mediated Tumor Surveillance
Cancers 6(1), 193–210 (2014)
Reinmuth-Selzle K, Ackaert C, Kampf CJ, Samonig M, Shiraiwa M, Kofler S, Yang H, Gadermaier G, Brandstetter H, Huber CG, Duschl A, Oostingh GJ, Pöschl U
Nitration of the Birch Pollen Allergen Bet v 1.0101: Efficiency and Site-Selectivity of Liquid and Gaseous Nitrating Agents
J Proteome Res 13(3), 1570–1577 (2014)
Skala W, Utzschneider DT, Magdolen V, Debela M, Guo S, Craik CS, Brandstetter H, Goettig P
Structure-Function Analyses of Human Kallikrein-related Peptidase 2 Establish the 99-Loop as Master Regulator of Activity
J Biol Chem 289(49), 34267–34283 (2014)
2013
Eckhard U, Schönauer E, Brandstetter H
Structural Basis for Activity Regulation and Substrate Preference of Clostridial Collagenases G, H, and T
J Biol Chem 288(28), 20184–20194 (2013)
Gusenkov S, Ackaert C, Stutz H
Separation and characterization of nitrated variants of the major birch pollen allergen by CZE-ESI-µTOF MS
Electrophoresis 34(18), 2695–2704 (2013)
Hessenberger M, Weiss R, Weinberger EE, Boehler C, Thalhamer J, Scheiblhofer S
Transcutaneous delivery of CpG-adjuvanted allergen via laser-generated micropores
Vaccine 31(34), 3427–3434 (2013)
Kofler S, Ackaert C, Samonig M, Asam C, Briza P, Horejs-Hoeck J, Cabrele C, Ferreira F, Duschl A, Huber C, Brandstetter H
Stabilization of the Dimeric Birch Pollen Allergen Bet v 1 Impacts Its Immunological Properties
J Biol Chem 289(1), 540–551 (2013)
Laner-Plamberger S, Wolff F, Kaser-Eichberger A, Swierczynski S, Hauser-Kronberger C, Frischauf A, Eichberger T
Hedgehog/GLI Signaling Activates Suppressor of Cytokine Signaling 1 (SOCS1) in Epidermal and Neural Tumor Cells
PLoS One 8(9), e75317 (2013)
Pichler U, Asam C, Weiss R, Isakovic A, Hauser M, Briza P, Ferreira F, Wallner M
The Fold Variant BM4 Is Beneficial in a Therapeutic Bet v 1 Mouse Model
BioMed Res Int 2013, 1–5 (2013)
Pollheimer P, Taskinen B, Scherfler A, Gusenkov S, Creus M, Wiesauer P, Zauner D, Schöfberger W, Schwarzinger C, Ebner A, Tamp{\'{e}} R, Stutz H, Hytönen VP, Gruber HJ
Reversible Biofunctionalization of Surfaces with a Switchable Mutant of Avidin
Bioconjugate Chem 24(10), 1656–1668 (2013)
Roulias A, Pichler U, Hauser M, Himly M, Hofer H, Lackner P, Ebner C, Briza P, Bohle B, Egger M, Wallner M, Ferreira F
Differences in the intrinsic immunogenicity and allergenicity of Bet v 1 and related food allergens revealed by site-directed mutagenesis
Allergy 69(2), 208–215 (2013)
Schwarz H, Posselt G, Wurm P, Ulbing M, Duschl A, Horejs-Hoeck J
TLR8 and NOD signaling synergistically induce the production of IL-1β and IL-23 in monocyte-derived DCs and enhance the expression of the feedback inhibitor SOCS2
Immunobiology 218(4), 533–542 (2013)
Selzle K, Ackaert C, Kampf CJ, Kunert AT, Duschl A, Oostingh GJ, Pöschl U
Determination of nitration degrees for the birch pollen allergen Bet v 1
Anal Bioanal Chem 405(27), 8945–8949 (2013)
Weinberger EE, Himly M, Myschik J, Hauser M, Altmann F, Isakovic A, Scheiblhofer S, Thalhamer J, Weiss R
Generation of hypoallergenic neoglycoconjugates for dendritic cell targeted vaccination: A novel tool for specific immunotherapy
J Controlled Release 165(2), 101–109 (2013)
Weinberger EE, Isakovic A, Scheiblhofer S, Ramsauer C, Reiter K, Hauser-Kronberger C, Thalhamer J, Weiss R
The influence of antigen targeting to sub-cellular compartments on the anti-allergic potential of a DNA vaccine
Vaccine 31(51), 6113–6121 (2013)
Weiss R, Scheiblhofer S, Machado Y, Thalhamer J
New approaches to transcutaneous immunotherapy
Curr Opin Allergy Clin Immunol 13(6), 669–676 (2013)
Wenger J, Klinglmayr E, Fröhlich C, Eibl C, Gimeno A, Hessenberger M, Puehringer S, Daumke O, Goettig P
Functional Mapping of Human Dynamin-1-Like GTPase Domain Based on X-ray Structure Analyses
PLoS One 8(8), e71835 (2013)
Wolff F, Loipetzberger A, Gruber W, Esterbauer H, Aberger F, Frischauf AM
Imiquimod directly inhibits Hedgehog signalling by stimulating adenosine receptor/protein kinase A-mediated GLI phosphorylation
Oncogene 32(50), 5574–5581 (2013)
Zucchetto A, Caldana C, Benedetti D, Tissino E, Rossi FM, Hutterer E, Pozzo F, Bomben R, Bo MD, D’Arena G, Zaja F, Pozzato G, Raimondo FD, Hartmann TN, Rossi D, Gaidano G, Poeta GD, Gattei V
CD49d is overexpressed by trisomy 12 chronic lymphocytic leukemia cells: evidence for a methylation-dependent regulation mechanism
Blood 122(19), 3317–3321 (2013)
2012
Aberger F, Kern D, Greil R, Hartmann TN
Canonical and Noncanonical Hedgehog/GLI Signaling in Hematological Malignancies
in: Hedgehog Signal, Elsevier (2012), 25–54
Asslaber D, Grössinger EM, Girbl T, Hofbauer SW, Egle A, Weiss L, Greil R, Hartmann TN
Mimicking the microenvironment in chronic lymphocytic leukaemia – where does the journey go?
Br J Haematol 160(5), 711–714 (2012)
Bach D, Weiss R, Hessenberger M, Kitzmueller S, Weinberger EE, Krautgartner WD, Hauser-Kronberger C, Boehler C, Thalhamer J, Scheiblhofer S
Transcutaneous immunotherapy via laser-generated micropores efficiently alleviates allergic asthma in Phl p 5-sensitized mice
Allergy 67(11), 1365–1374 (2012)
Eberl M, Klingler S, Mangelberger D, Loipetzberger A, Damhofer H, Zoidl K, Schnidar H, Hache H, Bauer H, Solca F, Hauser-Kronberger C, Ermilov AN, Verhaegen ME, Bichakjian CK, Dlugosz AA, Nietfeld W, Sibilia M, Lehrach H, Wierling C, Aberger F
Hedgehog-EGFR cooperation response genes determine the oncogenic phenotype of basal cell carcinoma and tumour-initiating pancreatic cancer cells
EMBO Mol Med 4(3), 218–233 (2012)
Eibl C, Grigoriu S, Hessenberger M, Wenger J, Puehringer S, Pinheiro AS, Wagner RN, Proell M, Reed JC, Page R, Diederichs K, Peti W
Structural and Functional Analysis of the NLRP4 Pyrin Domain
Biochemistry (Mosc) 51(37), 7330–7341 (2012)
Girbl T, Hinterseer E, Grossinger EM, Asslaber D, Oberascher K, Weiss L, Hauser-Kronberger C, Neureiter D, Kerschbaum H, Naor D, Alon R, Greil R, Hartmann TN
CD40-Mediated Activation of Chronic Lymphocytic Leukemia Cells Promotes Their CD44-Dependent Adhesion to Hyaluronan and Restricts CCL21-Induced Motility
Cancer Res 73(2), 561–570 (2012)
Horejs-Hoeck J, Schwarz H, Lamprecht S, Maier E, Hainzl S, Schmittner M, Posselt G, Stoecklinger A, Hawranek T, Duschl A
Dendritic Cells Activated by IFN-γ/STAT1 Express IL-31 Receptor and Release Proinflammatory Mediators upon IL-31 Treatment
J Immunol 188(11), 5319–5326 (2012)
Klinglmayr E, Wenger J, Mayr S, Bossy-Wetzel E, Puehringer S
Purification, crystallization and X-ray diffraction analysis of human dynamin-related protein 1 GTPase-GED fusion protein
Acta Crystallogr F Struct Biol Cryst Commun 68(10), 1217–1221 (2012)
Kofler S, Asam C, Eckhard U, Wallner M, Ferreira F, Brandstetter H
Crystallographically Mapped Ligand Binding Differs in High and Low IgE Binding Isoforms of Birch Pollen Allergen Bet v 1
J Mol Biol 422(1), 109–123 (2012)
Mangelberger D
Cooperative Hedgehog-EGFR signaling
Front Biosci 17(1), 90 (2012)
Pichler P, Mazanek M, Dusberger F, Weilnböck L, Huber CG, Stingl C, Luider TM, Straube WL, Köcher T, Mechtler K
SIMPATIQCO: A Server-Based Software Suite Which Facilitates Monitoring the Time Course of LC-MS Performance Metrics on Orbitrap Instruments
J Proteome Res 11(11), 5540–5547 (2012)
Rieder G, Krisch L, Fischer H, Kaufmann M, Maringer A, Wessler S
Carnobacterium divergens – a dominating bacterium of pork meat juice
FEMS Microbiol Lett 332(2), 122–130 (2012)
Stoecklinger A, Scheiblhofer S, Roesler E, Lang A, Fastner G, Sedlmayer F, Lang R, Danzer M, Thalhamer J, Weiss R
T Cell Epitopes of the Timothy Grass Pollen Allergen Phl p 5 of Mice and Men and the Detection of Allergen-Specific T Cells Using Class II Ultimers
Int Arch Allergy Immunol 158(4), 326–334 (2012)
Weiss R, Hessenberger M, Kitzmüller S, Bach D, Weinberger EE, Krautgartner WD, Hauser-Kronberger C, Malissen B, Boehler C, Kalia YN, Thalhamer J, Scheiblhofer S
Transcutaneous vaccination via laser microporation
J Controlled Release 162(2), 391–399 (2012)
Weiss R, Scheiblhofer S, Roesler E, Weinberger E, Thalhamer J
mRNA vaccination as a safe approach for specific protection from type I allergy
Expert Rev Vaccines 11(1), 55–67 (2012)
2011
Ackaert C, Kofler S, Posselt G, Gusenkov S, Gadermaier G, Asam C, Stutz H, Brandstetter H, Duschl A, Horejs-Höck J, Oostingh GJ
Impact of nitration on the immunogenicity of Bet v 1.0101
Immunology 135, 52–212 (2011)
Brachtl G, Sahakyan K, Denk U, Girbl T, Alinger B, Hofbauer SW, Neureiter D, Hofbauer JP, Egle A, Greil R, Hartmann TN
Differential Bone Marrow Homing Capacity of VLA-4 and CD38 High Expressing Chronic Lymphocytic Leukemia Cells
PLoS One 6(8), e23758 (2011)
Eckhard U, Schönauer E, Nüss D, Brandstetter H
Structure of collagenase G reveals a chew-and-digest mechanism of bacterial collagenolysis
Nat Struct Mol Biol 18(10), 1109–1114 (2011)
Erler A, Hawranek T, Krückemeier L, Asam C, Egger M, Ferreira F, Briza P
Proteomic profiling of birch (Betula verrucosa) pollen extracts from different origins
Proteomics 11(8), 1486–1498 (2011)
Hauser M, Asam C, Himly M, Palazzo P, Voltolini S, Montanari C, Briza P, Bernardi ML, Mari A, Ferreira F, Wallner M
Bet v 1-like pollen allergens of multiple Fagales species can sensitize atopic individuals
Clin Exp Allergy 41(12), 1804–1814 (2011)
Pinheiro AS, Eibl C, Ekman-Vural Z, Schwarzenbacher R, Peti W
The NLRP12 Pyrin Domain: Structure, Dynamics, and Functional Insights
J Mol Biol 413(4), 790–803 (2011)
Posselt G, Schwarz H, Duschl A, Horejs-Hoeck J
Suppressor of Cytokine Signaling 2 Is a Feedback Inhibitor of TLR-Induced Activation in Human Monocyte-Derived Dendritic Cells
J Immunol 187(6), 2875–2884 (2011)
Wallner M, Hauser M, Himly M, Zaborsky N, Mutschlechner S, Harrer A, Asam C, Pichler U, Ree R, Briza P, Thalhamer J, Bohle B, Achatz G, Ferreira F
Reshaping the Bet v 1 fold modulates TH polarization
J Allergy Clin Immunol 127(6), 1571–1578.e9 (2011)
2010
Desch P, Asslaber D, Kern D, Schnidar H, Mangelberger D, Alinger B, Stoecher M, Hofbauer SW, Neureiter D, Tinhofer I, Aberger F, Hartmann TN, Greil R
Inhibition of GLI, but not Smoothened, induces apoptosis in chronic lymphocytic leukemia cells
Oncogene 29(35), 4885–4895 (2010)
Hauser M, Roulias A, Ferreira F, Egger M
Panallergens and their impact on the allergic patient
Allergy Asthma Cl Im 6(1), 1 (2010)
Maier E, Hebenstreit D, Posselt G, Hammerl P, Duschl A, Horejs-Hoeck J
Inhibition of Suppressive T Cell Factor 1 (TCF-1) Isoforms in Naive CD4+T Cells Is Mediated by IL-4/STAT6 Signaling
J Biol Chem 286(2), 919–928 (2010)
Pinheiro AS, Proell M, Eibl C, Page R, Schwarzenbacher R, Peti W
Three-dimensional Structure of the NLRP7 Pyrin Domain
J Biol Chem 285(35), 27402–27410 (2010)
Stoecklinger A, Eticha TD, Mesdaghi M, Kissenpfennig A, Malissen B, Thalhamer J, Hammerl P
Langerin+ Dermal Dendritic Cells Are Critical for CD8 T Cell Activation and IgH γ-1 Class Switching in Response to Gene Gun Vaccines
J Immunol 186(3), 1377–1383 (2010)
Weiss R, Scheiblhofer S, Roesler E, Ferreira F, Thalhamer J
Prophylactic mRNA vaccination against allergy
Curr Opin Allergy Clin Immunol 10(6), 567–574 (2010)
2009
Eckhard U, Schönauer E, Ducka P, Briza P, Nüss D, Brandstetter H
Biochemical characterization of the catalytic domains of three different clostridial collagenases
Biol Chem 390(1), (2009)
Roesler E, Weiss R, Weinberger EE, Fruehwirth A, Stoecklinger A, Mostböck S, Ferreira F, Thalhamer J, Scheiblhofer S
Immunize and disappear – Safety-optimized mRNA vaccination with a panel of 29 allergens
J Allergy Clin Immunol 124(5), 1070–1077.e11 (2009)
Schnidar H, Eberl M, Klingler S, Mangelberger D, Kasper M, Hauser-Kronberger C, Regl G, Kroismayr R, Moriggl R, Sibilia M, Aberger F
Epidermal Growth Factor Receptor Signaling Synergizes with Hedgehog/GLI in Oncogenic Transformation via Activation of the MEK/ERK/JUN Pathway
Cancer Res 69(4), 1284–1292 (2009)
Wallner M, Himly M, Neubauer A, Erler A, Hauser M, Asam C, Mutschlechner S, Ebner C, Briza P, Ferreira F
The Influence of Recombinant Production on the Immunologic Behavior of Birch Pollen Isoallergens
PLoS One 4(12), e8457 (2009)
2008
Eichberger T, Kaser A, Pixner C, Schmid C, Klingler S, Winklmayr M, Hauser-Kronberger C, Aberger F, Frischauf A
GLI2-specific Transcriptional Activation of the Bone Morphogenetic Protein/Activin Antagonist Follistatin in Human Epidermal Cells
J Biol Chem 283(18), 12426–12437 (2008)
