Signal sender
Proteases
How do members of the ADAM protease family regulate tumorigenesis and metastasis?
![ADAM proteases shed ectodomains of cytokines](https://www.plus.ac.at/wp-content/uploads/2021/09/TS_48.png)
Signal molecules
Cytokines
How become cytokines selective? And how are they spatio-temporally regulated in the tumour micro-environment?
![cytokines have different cellular targets](https://www.plus.ac.at/wp-content/uploads/2021/09/Figure_1a.png)
Signal receiver
Immunity
How does the immune system influence tumorigenesis? How can we boost anti-tumour immunity?
![Innate and adaptive immune cells are involved in anti-tumour immunity.](https://www.plus.ac.at/wp-content/uploads/2021/09/Fig2c.png)