List of publications

As of 09/2024

PUBLICATIONS HOREJS-HOECK

PEER-REVIEWED PUBLICATIONS (2016 – 2024)

2024

  1. Ribeiro ARS, Neuper T, Horejs-Hoeck J. The Role of STING-Mediated Activation of Dendritic Cells in Cancer Immunotherapy. Int J Nanomedicine. 2024 Oct 22;19:10685-10697. doi: 10.2147/IJN.S477320
  2. Neuper T, Frauenlob T, Dang HH, Krenn PW, Posselt G, Regl C, Fortelny N, Schäpertöns V, Unger MS, Üblagger G, Neureiter D, Mühlbacher I, Weitzendorfer M, Singhartinger F, Emmanuel K, Huber CG, Wessler S, Aberger F, Horejs-Hoeck J. ADP-heptose attenuates Helicobacter pylori-induced dendritic cell activation. Gut Microbes. 2024 Jan-Dec;16(1):2402543. doi: 10.1080/19490976.2024.2402543
  3. Luciano M, Sieberer H, Krenn PW, Dang HH, Vetter J, Neuper T, Amend D, Blöchl C, Weichenberger CX, Eglseer A, Unger MS, Andosch A, Steiner P, Neureiter D, Bauer R, Hummer L, Tesanovic S, Binder S, Elmer DP, Strandt H, Schaller S, Strunk D, Pleyer L, Greil R, Winkler S, Hartmann TN, Schmidt-Arras D, Huber CG, Aberger F, Horejs-Hoeck J. Targeting NLRP3 inhibits AML progression by inducing PERK/eIF2-mediated apoptosis. Cell Commun Signal. 2024 Sep 2;22(1):424. doi: 10.1186/s12964-024-01777-6
  4. Bauer R, Dang HH, Neureiter D, Unger MS, Neuper T, Jensen M, Taliento AE, Strandt H, Gratz I, Weiss R, Sales A, Horejs-Hoeck J. NLRP3 promotes allergic responses to birch pollen extract in a model of intranasal sensitization. Front Immunol. 2024 Jun 12;15:1393819. doi: 10.3389/fimmu.2024.1393819
  5. Fux AC, Casonato Melo C, Schlahsa L, Burzan NB, Felsberger A, Gessner I, Fauerbach JA, Horejs-Hoeck J, Droste M, Siewert C. Generation of Endotoxin-Specific Monoclonal Antibodies by Phage and Yeast Display for Capturing Endotoxin. Int J Mol Sci. 2024 Feb 15;25(4):2297. doi: 10.3390/ijms25042297

2023

  1. Frauenlob, T., Neuper, T., Regl, C., Oswald, A-L., Schäpertöns, V., Dang, HH., Unger, M. S., Huber C. G., Wessler, S., Horejs-Hoeck, J. Helicobacter pylori induces a novel form of innate immune memory via accumulation of NF-κB proteins. Front Immunol 2023 Nov 20:14:1290833. doi: 10.3389/fimmu.2023.1290833
  2. Urwanisch L, Unger MS, Sieberer H, Dang HH, Neuper T, Regl C, Vetter J, Schaller S, Winkler SM, Kerschbamer E, Weichenberger CX, Krenn PW, Luciano M, Pleyer L, Greil R, Huber CG, Aberger F, Horejs-Hoeck J.
  3. Johnson L, Aglas L, Punz B, Dang HH, Christ C, Pointner L, Wenger M, Hofstaetter N, Hofer S, Geppert M, Andosch A, Ferreira F, Horejs-Hoeck J, Duschl A, Himly M. Mechanistic insights into silica nanoparticle-allergen interactions on antigen presenting cell function in the context of allergic reactions. Nanoscale. 2023 Feb 2;15(5):2262-2275. doi: 10.1039/d2nr05181h

2022

  1. Barbero, F.; Michelini, S.; Moriones, OH.; Patarroyo, J.; Rosell, JF.; Gusta, M.; Vitali, M.; Martín, L.; Canals, F.; Duschl, A.; Horejs-Hoeck, J.; Mondragón, L.; Bastús, NG.; Puntes, V. Role of Common Cell Culture Media Supplements on Citrate-Stabilized Gold Nanoparticle Protein Corona Formation, Aggregation State, and the Consequent Impact on Cellular Uptake. Bioconjug Chem. 2022 doi: 10.1021/acs.bioconjchem.2c00232
  2. Punz, B.; Johnson, L.; Geppert, M.; Dang, HH.; Horejs-Hoeck, J.; Duschl, A.; Himly, M. Surface Functionalization of Silica Nanoparticles: Strategies to Optimize the Immune-Activating Profile of Carrier Platforms. Pharmaceutics 2022 doi: 10.3390/pharmaceutics14051103
  3. Neuper, T.; Frauenlob, T.; Posselt G.P.; Horejs-Hoeck, J. Beyond the gastric epithelium – the paradox of Helicobacter pylori-induced immune responses. Current Opinion in Immunology 2022, doi: 10.1016/j.coi.2022.102208
  4. Frauenlob, T.; Neuper, T.; Mehinagic, M.; Dang, HH.; Boraschi, D.; Horejs-Hoeck, J., Helicobacter pylori Infection of Primary Human Monocytes Boosts Subsequent Immune Responses to LPS. Front Immunol 2022, doi: 10.3389/fimmu.2022.847958
  5. Samadi, N.; Koidl, L.; Salzmann, M.; Klems, M.; Komatitsch, N.; Schaffer, D.; Weidmann, E.; Duschl, A.; Horejs-Hoeck, J.; Untersmayr, E. Food Allergen Nitration Enhances Safety and Efficacy of Oral Immunotherapy in Food Allergy. Nutrients 2022, doi.org/10.3390/nu14071373
  6. Neuper, T.; Weiss, R.; Horejs-Hoeck, J. Ripping the Ripoptosome: a novel path for blocking allergic inflammation? Cellular & Molecular Immunology 2022, doi: 10.1038/s41423-021-00815-4

2021

  1. Blöchl, C.; Holzner, C.; Luciano, M.; Bauer, R.; Horejs-Hoeck, J.; Eckhard, U.; Brandstetter, H.; Huber, C. G., Proteolytic Profiling of Streptococcal Pyrogenic Exotoxin B (SpeB) by Complementary HPLC-MS Approaches. Int J Mol Sci 2021, doi:3390/ijms23010412
  2. Swartzwelter, B.J.; Michelini, S.; Frauenlob, T.; Barbero, F.; Verde, A.; De Luca, A.C.; Puntes, V.; Duschl, A.; Horejs-Hoeck, J.; Italiani, P.;  Boraschi, D. Innate memory reprogramming by gold nanoparticles depends on the microbial agents that induce memory. Front Immunol 2021, doi: 10.3389/fimmu.2021.751683
  3. Michelini, S.; Barbero, F.; Prinelli, A.; Steiner, Ph.; Weiss, R.; Verwanger, T.; Andosh, A.; Lütz-Meindl, U.; Puntes, V.F.; Drobne, D.; Duschl, A.; Horejs-Hoeck, J. Gold Nanoparticles (AuNPs) Impair LPS-driven Immune Responses by Promoting a Tolerogenic-like Dendritic Cell Phenotype with Altered Endosomal Structures, Nanoscale, 2021, doi:10.1039/d0nr09153g
  4. Urwanisch, L.; Luciano, M.; Horejs-Hoeck, J. The NLRP3 Inflammasome and Its Role in the Pathogenicity of Leukemia. J. Mol. Sci. 2021, doi.org/10.3390/ijms22031271
  5. Neuper, T., Neureiter. , Schwarz, H., Sarajlic, M., Bauer, R., Strandt, H., Suchanek, P., Dillon, S.R., Stoecklinger, A., Hammerl, P., Weiss, R., and Horejs-Hoeck, J. Reduced allergen-induced lung inflammation in IL-31 transgenic mice, European Journal of Immunology, 2021, doi.org/10.1002/eji.202048547
  6. Korotchenko, E.; Schießl, V.; Scheiblhofer, S.; Joubert, I.A.; Strandt, H.; Neuper, T.; Sarajlic,M.;  Bauer, R.; Geppert, M.; Joedicke, D.; SWildner, S.; Schaller, S.; Winkler, S.; Gadermaier, G.; Horejs-Hoeck, J.; Weiss R.; Laser-facilitated epicutaneous immunotherapy with hypoallergenic beta-glucan neoglycoconjugates suppresses lung inflammation and avoids local side effects in a mouse model of allergic asthma, Allergy, 2021, doi: 10.1111/all.14481

2020

  1. Sarajlic M, Neuper T, Vetter J, Schaller S, Klicznik M, Gratz I, Wessler S, Posselt G, Horejs-Hoeck J. H. pylori modulates DC functions via T4SS/TNFα/p38-dependent SOCS3 expression. Cell Commun Signal, 2020, doi: 10.1186/s12964-020-00655-1
  2. Pinsino, A.;  Bastús, N.G.; Busquets-Fité, M.; Canesi, L.; Cesaroni, P.; Drobne,D.; Duschl, A.;   Ewart, M.; Gispert, I.; Horejs-Hoeck, J.; Italiani,P.;  Kemmerling, B.; Kille, P.; Procházková, P.;  Puntes, V.F.; Spurgeon, D.J.; Svendsen, C.; Wilde, C.J.; Boraschi, D.; Probing the immune responses to nanoparticles across environmental species. A perspective of the EU Horizon 2020 project PANDORA. Sci.: Nano, 2020, 7, 3216-3232, doi.org/10.1039/D0EN00732C
  3. Chichirau BE, Scheidt T, Diechler S, Neuper T, Huber C, Horejs-Hoeck J, Posselt G, Wessler S. Dissecting the Helicobacter pylori-regulated transcriptome of B cells. Pathog Dis, 2020, Aug 31:ftaa049. doi: 10.1093/femspd/ftaa049
  4. Winter, P.; Stubenvoll, S.; Scheiblhofer, S.; Joubert, I.A.; Strasser, L.; Briganser, C.; Soh, W.T.; Hofer, F.; Kamenik, A.S.; Dietrich, V.; Michelini, S.; Laimer, J.; Lackner, P.; Horejs-Hoeck, J.; Tollinger, M.; Liedl,K.R.;  Brandstetter, J.; Huber, C.G.; Weiss, R. “In silico design of Phl p 6 variants with altered folding stability significantly impacts antigen processing, immunogenicity and immune polarization”, Frontiers in Immunology, 2020, doi: 10.3389/fimmu.2020.01824
  5. Klicznik Maria M., Ariane Benedetti, Laura M. Gail, Suraj R. Varkhande, Raimund Holly, Martin Laimer, Angelika Stoecklinger, Andreas Sir, Roland Reitsamer, Theresa Neuper, Jutta Horejs-Hoeck, Michael D. Rosenblum, Daniel J. Campbell, Eva M. Murauer, Iris K. Gratz A novel humanized mouse model to study the function of human cutaneous memory T cells in vivo in human skin. Scientific Reports, 2020, doi: 10.1038/s41598-020-67430-7
  6. Neuper, T.; Frauenlob, T.; Sarajlic, M.; Posselt, G.; Wessler, S.; Horejs-Hoeck, J.; TLR2, TLR4 and TLR10 shape the cytokine and chemokine release of H. pylori-infected human DCs. Int J Mol Sci, 2020 May 29;21(11):E3897. doi: 10.3390/ijms21113897
  7. Joubert, I.A.; Geppert, M.; Johnson, L.; Mills-Goodlet, T.; Michelini, S.; Korotchenko, E.; Duschl, A.; Weiss, R.; Horejs-Höck, J.; Himly, M.; Mechanisms of particles in sensitization, effector function and therapy of allergic disease, Frontiers in Immunology, 2020, Jun 30;11:1334. doi: 10.3389/fimmu.2020.01334
  8. Korotchenko, E.; Moya, R.; Scheiblhofer, S.; Joubert, I.A.; Horejs-Hoeck, J., Hauser, M.; Calzada, D.; Iraola, ; Carnés, J.; Weiss, R.; Laser-facilitated epicutaneous immunotherapy with depigmented house dust mite extract alleviates allergic responses in a mouse model of allergic lung inflammation. Allergy, 2020 May;75(5):1217-1228. doi: 10.1111/all.14164
  9. Boraschi, D.; Alijagic, A.; Auguste. M.; Barbero, F.; Ferrari, E.; Hernadi, S.; Mayall, C.; Michelini, S.; Navarro Pacheco, N.I., Prinelli, A.; Swart, E.; Swartzwelter, B.J.; Bastús, N.G.; Canesi, L.; Drobne, D.; Duschl, A.; Ewart, M.; Horejs-Hoeck, J.; Italiani, P.; Kemmerling, B.; Kille, P.; Prochazkova, Puntes, V.F.; Spurgeon, D.V.; Svendsen, C.; Wilde, C.J.; Pinsino, A.;  Addressing Nanomaterial Immunosafety by Evaluating Innate Immunity across Living Species. 2020 May 4:e2000598. doi: 10.1002/smll.202000598
  10. Himly, M.; Geppert, M.; Hofer, S.; Hofstätter, N.; Horejs-Höck, J.; Duschl, A.; When Would Immunologists Consider a Nanomaterial to be Safe? Recommendations for Planning Studies on Nanosafety. Small 2020. DOI smll.201907483

2019-2016

  1. Sarajlic, M.; Neuper, T.; Fohrenbach Quiroz, K. T.; Michelini, S.; Vetter, J.; Schaller, S.; Horejs-Hoeck, J., IL-1β Induces SOCS2 Expression in Human Dendritic Cells. Int J Mol Sci 2019, 20 (23). DOI 10.3390/ijms20235931
  2. Samadi N, Klems M, Heiden D, Bauer R, Kitzmüller C, Weidmann E, Ret D, Ondracek AS, Duschl A, Horejs-Hoeck J, Untersmayr E. Nitrated food proteins induce a regulatory immune response associated with allergy prevention after oral exposure in a Balb/c mouse food allergy model, Allergy, 2019, Aug 24. doi: 10.1111/all.14030
  3. Aglas L, Gilles S, Bauer R, Huber S, Araujo GR, Mueller G, Scheiblhofer S, Amisi M, Dang HH, Briza P, Bohle B, Horejs-Hoeck J, Traidl-Hoffmann C, Ferreira F. Context matters: Th2 polarization resulting from pollen composition and not from protein-intrinsic allergenicity. J Allergy Clin Immunol, 2018, 18: 30711-30715. doi: 10.1016/j.jaci.2018.05.004
  4. Michelini S, Sarajlic M, Duschl A, Horejs-Hoeck J. Dendritic cell activation and feedback inhibition in sterile and non-sterile inflammation. Hum Immunol, 2018, 79:610-615. doi: 10.1016/j.humimm.2018.06.002
  5. Binder S, Luciano M, Horejs-Hoeck, J. The Cytokine Network in Acute Myeloid Leukemia (AML): A Focus on Pro- and Anti-Inflammatory Mediators, Cytokine and Growth Factor reviews, 2018, Oct;43:8-15. doi: 10.1016/j.cytogfr.2018.08.004
  6. Strasser L, Schwarz H, Dang HH, Asam C, Ferreira F, Horejs-Hoeck J, Huber CG. Unbiased Quantitative Proteomics Reveals a Crucial Role of the Allergen Context for the Activation of Human Dendritic Cells. Sci Rep, 2017, 7:16638. doi: 10.1038/s41598-017-16726-2
  7. Li Y, Zhenzhen S, Radauer-Preiml  I,  Ancuela A, Casals  E, Luetz-Meindl U, Cobal M, Zhoumeng  L,  Jaberi-Douraki M, Italiani P,  Horejs-Hoeck  J,  Himly M,  Monteiro-Riviere NA, Duschl A, Puntes V,  Boraschi D. Bacterial endotoxin (LPS) binds to the surface of gold nanoparticles, interferes with biocorona formation and induces human monocyte inflammatory activation. Nanotoxicology, 2017, 11:1157-1175. doi: 10.1080/17435390
  8. Neuper T, Ellwanger K, Schwarz H, Kufer TA, Duschl A, Horejs-Hoeck J. NOD1 modulates IL-10 signalling in human dendritic cells. Sci Rep, 2017, 7:1005. doi: 10.1038/s41598-017-00691-x
  9. Schwarz H, Gornicec J, Neuper T, Parigiani MA, Wallner M, Duschl A, Reich J, Horejs-Hoeck J. Biological Activity of Masked Endotoxin. Sci Rep, 2017, 7: 44750. doi: 10.1038/srep44750
  10. Radauer-Preiml I, Andosch A, Hawranek T, Luetz-Meindl U, Huber C, Wiederstein M, Horejs-Hoeck J, Himly M, Boyles MSP, Duschl A. Human allergic response modulated by interactions of allergens with gold nanoparticles – protein corona characterization and basophil response, Part Fibre Toxicol, 2016, 3: 3. doi: 10.1186/s12989-016-0113-0
  11. Steiner M, Hawranek T, Schneider M, Harrer A, Horejs-Hoeck J, Ferreira F, Himly M. Elevated Toll-like receptor-induced CXCL8 secretion in human blood basophils from allergic donors is independent of Toll-like receptor expression levels. PlosOne, 2016 11: e0149275. doi: 10.1371/journal.pone.0149275
  12. Maier E, Mittermaier M, Ess S, Neuper T, Schmiedlechner A, Duschl A, Horejs-Hoeck J. Prerequisites for functional Interleukin 31 Signaling and Feedback Regulation by Suppressors of Cytokine Signaling (SOCS). J Biol Chem, 2015, 290: 24747-24759. doi: 10.1074/jbc.M115.661306
  13. Machado Y, Freier R, Scheiblhofer S, Thalhamer T, Mayr M, Briza P, Grutsch S, Ahammer L, Fuchs J, Wallnöfer H, Isakovic A, Kohlbauer V, Hinterholzer A, Steiner M, Danzer M, Horejs-Hoeck J, Ferreira F, Liedl KR, Tollinger M, Lackner P, Johnson CM, Brandstetter H, Thalhamer J, Weiss R. Fold-stability during endolysosomal acidification is a key factor for allergenicity and immunogenicity of the major birch pollen allergen. J Allergy Clin Immunol, 2015, 7: 1525-1534. doi:10.1016/j.jaci.2015.09.026

                                                                                                                                 

NON-PEER-REVIEWED PUBLICATIONS (2020 – 2024)

  1. Elmer, D.P.; Strobl, V.; Stockmaier, G.; Dang, H.H.; Wiederstein, M.; Licha, D.; Strobl, A.; Sternberg, C.; Tesanovic, S.; Grund-Groeschke, S.;  Gruber, W.;  Wolff,F.;  Moriggl, R.;  Risch, A.;  Reischl, R.;  Huber, C.G.; Horejs-Hoeck, J.;  Aberger, G.; Oncogenic GLI1 and STAT1/3 activation drives immunosuppressive tryptophan/kynurenine metabolism via synergistic induction of IDO1 in skin cancer cells, bioRxiv 2020 DOI.org/10.1101/2020.05.04.074757