Master Position in Skin Immunology:“HDACs as regulators of immunity”

We invite applications for a full time Master position in our “ Tissue Immune Regulation” group. Our research group focuses on the role of T cells in skin. The candidate will be part of a team working on the regulation of T cell responses in the skin in mice. Special focus will be on the role of epigenetic regulators, HDACs, in regulatory T cells. The project will be performed in the context of a multi-group consortium (an  FWF-funded SFB) focused on HDAC biology in T cells. We can offer close interaction with multiple research groups in Vienna that offer expertise in Bioinformatics, Epigenetics, Proteomics and anti-microbial immune responses. Responsibilities: The applicant will be responsible for performing their own experiments with guidance from a PhD student within the research team. Specifically, the candidate will work with in vivo models of skin autoimmunity, gain in-depth experience in flow cytometry and T cell biology. Profile: We are looking forward to applications from highly motivated Biologists. Applicants should have a background (class work) in cellular and molecular immunology and be willing to perform in vivo experiments involving mice. Beneficial would be basic knowledge of flow cytometry. Offer: We offer training in functional cellular assays using immune cells as well as skin tissue cells. You will gain experience in flow cytometry, mouse handling, and expand on your understanding of Immunology. Option to receive part-time employment (“geringfügige Anstellung”).
Starting date as soon as possible.

Master Position in Skin Tumor Immunology

We invite applications for a full time Master position in the “ Tissue Immune Regulation” group of Iris Gratz, PhD. Our research group focuses on the role of tissue-resident T cells in health and disease. The candidate will be part of a team studying gamma delta T cells, a unique subset of immune cells. These cells are known to play a role in the regulation of skin immunity, and we will study the role of gamma delta cells in the context of cutaneous squamous cell carcinomas (SCCs). The main focus of the project will be to establish a humanized in vivo SCC tumor mouse model with the aim to study innovative therapeutic approaches, exploiting the anti-tumor activity of gamma delta cells. In addition, as part of a larger research consortium focused on dermatological research (the  EB House Austria, we can offer close interaction with clinicians, which promotes access to patient material and translation of new findings to the clinic. Responsibilities: The applicant will be responsible for performing their own experiments with guidance from a Postdoctoral researcher within the research team. Profile: We are looking forward to applications from highly motivated Biologists. Applicants should have a background (class work) in cellular and molecular immunology.  Beneficial (but not required) will be knowledge of animal handling, cell culture and flow cytometry. Offer: You will gain experience in performing both in vivo and in vitro experiments. We offer training in mouse handling, flow cytometry and functional cellular assays using immune cells as well as skin tissue cells. Therefore, you will acquire a spectrum of techniques that are important in the field of immunology. Option to receive part-time employment (“geringfügige Anstellung”). Starting date: As soon as possible.

 

1.5 Staff Research Assistant (SRA) positions- both positions are filled

 

100% employment, 40 hours/week

50% employment, 20 hours/week

Start date: January 2024 (as soon as possible)

The principal goal of our research is to understand the role of cutaneous T cells in skin inflammation,regeneration and cancer. We utilize organotypic 3D-skin cultures, mouse models of T cell-mediatedskin inflammation and unique humanized xenografting mouse models (including tumor tissue) toelucidate mechanisms of immune regulation and to perform preclinical studies.More information: https://www.plus.ac.at/gratz/

You will work in an international team with PhD students and Postdocs (working language English).

Duties:- Laboratory management, administrative duties- Genotyping of laboratory mice- Collaboration with other team members in basic research projects (preparation of tissue samples, isolation and culture of primary cells, in vivo experiments, injections, grafting procedures, cellular and molecular biological analysis)- Collaboration with clinical partners, working with patient’s samples (blood and skin) and maintenance of databases- Flow cytometry, immunohistochemistry/microscopy and other analysis methods to characterize murine and human skin and blood samples including data analysis

Requirements:– Bachelor of Science in Health Studies or Biomedical Sciences (FH) with laboratory experience, relevant technical high school education (HTL or HBLA), Bachelor’s or Master’s degree in Biology, Biochemistry, Biophysics or comparable programs.- Excellent spoken and written German- Fluent spoken and written English

Desirable additional qualifications:- Basic knowledge of Immunology- Excellent organizational skills- Interest in the development of new and innovative model systems- Experience in animal husbandry and handling

We specifically welcome applicants who:– Like to work in a team- Are reliable- Have the desire and aptitude to acquire new knowledge- Think creatively and critically

Salary: Depending on education and previous work experience- Range: 2.400 € – 2.900 € monthly gross salary for full time position (50% for part time)

Interested? For more information please contact Dr. Iris Gratz, Tel.: +43 662 8044-5764

Applications will be accepted until the position is filled. Applicants should submit an English application