The HENNER GRAEFF FOUNDATION – YOUNG INVESTIGATOR AWARD
We are excited that the HENNER GRAEFF FOUNDATION is sponsoring the Winterschool 2023 with three Young Investigator Awards.
Young investigators are awarded in recognition of their innovative approaches to their specific topics with a prize money of 1000.- EUR each.
Awardees:
2024
- Nele von Wiegen (University Medical Center of the Johannes Gutenberg University Mainz) Prevention of premature zona pellucida hardening by the endogenous Ovastacin inhibitor Fetuin-B is substitutable by small molecule compounds
- Aleksander Moldt Haack (Technical University of Denmark) A Fast Automated N-Terminome Analysis (FANTA) and Data Analysis Pipeline (CLIPPER 2.0)
- Samuel Zolg (University of Freiburg) Beyond a single proline: Determining substrate selectivity of Dipeptidyl-peptidase 9
- Kira Bickenbach (University of Kiel) The metalloprotease meprin β is a sheddase of the transferrin receptor I and influences iron metabolism
2023
- Sam Van Beljouw (Delft University of Technology) Craspase is a CRISPR RNA-guided, RNA-activated protease
- Frederic Buemi (Imperial College London) Detecting hydrolytic enzymes driving colorectal cancer
- Peter Grin (University of British Colombia) Defeating an antiviral interferon response by SARS-CoV-2 main protease (3CLpro) cleavage
2022
- Natasha Aley (University College London) ATG4B mediates beta catenin expression and 3D spheroid formation in pancreatic ductal adenocarcinoma
- Naiá Porã Santos (University of Salzburg) Functional analysis of phytocystatin 6 from Arabidopsis thaliana revealed amyloid fibril formation
- Konstantinos Kalogeropoulos (Technical University of Denmark, Kongens Lyngby) Proteomic and proteolytic landscape of acute human skin repair
2021
- Matthias Koch (KU Leuven) The mechanism securing GSEC-APP interactions and defining Aβ product length
- Jimin Hwang (University of Otago /NZ) Design, Synthesis and Biological Evaluation of Anti-chlamydial Covalent Inhibitors Targeting the Novel Bacterial Serine Protease CtHtrA
- Yekaterina Kovalyova (Yale University) An infection-activated redox switch in the lysosomal protease legumain promotes tumor growth
2020
- Alaa ALHAYEK (Saarland University & Helmholtz Institute for Pharmaceutical Research Saarland) Succinimides as novel pathoblocker agents targeting extracellular bacterial metalloproteases LasB and ColH
- Fred ARMBRUST (University of Kiel) APP processing in mouse brains shifts towards β-cleavage upon meprin β overexpression in astrocytes
- Cynthia COLMORGEN (University of Kiel) Cleavage of galectin-3 by meprin α and meprin β in intestinal mucosa
- Anna HOFMANN (University of Kiel) Capturing dynamic protein-protein interactions of intermembrane protease SPPL3
- Giulia MAGNO (Technical University of Munich) Evaluation of the tumor biological role of KLK4 in triple-negative breast cancer
- Kriti PATHAK (University of Kiel) Biochemical characterization of soluble ADAM10 and ADAM17
Best Chairing & Best Speaker – AWARD
| Year | Best Chairing | Best Speaker |
|---|---|---|
| 2024 | Tobias DREYER Technical University of Munich Achim KRÜGER Technical University of Munich Thomas REINHECKEL University of Freiburg Chris SCOTT Queen’s University Belfast | Emma CLYDE-ALLEN (Queen’s University Belfast) Development of Inhaled Small Molecule MPro Inhibitors for the Treatment of Respiratory Viral Infections Sascha RAHN (University of Kiel) Predictive and prognostic relevance of meprin α serum levels in sepsis Marta CAMPOS ALONSO (Universitätsklinikum Freiburg) Identifying the molecular mechanisms underlying the dual activity of USP18 Nele VON WIEGEN (University Medical Center of the Johannes Gutenberg University Mainz) Prevention of premature zona pellucida hardening by the endogenous Ovastacin inhibitor Fetuin-B is substitutable by small molecule compounds Fred ARMBRUST (University of Kiel) The metalloprotease meprin β is specifically inhibited by exogenous application of its propeptide Daniel HÄUSSLER (Technical University of Munich) On TIMP-1 glycosylation patterns in pancreatic cancer Julian FRÄDRICH (Technical University of Munich) The Cellular Source and Pancreatic Cancer Progression-Associated Expression of the Cytokine TIMP-1 Aleksander Moldt HAACK (Technical University of Denmark) A Fast Automated N-Terminome Analysis (FANTA) and Data Analysis Pipeline (CLIPPER 2.0) Anna CROIS (University of Freiburg) Non-Apoptotic signalling pathways involving caspase-8 Samuel ZOLG (University of Freiburg) Beyond a single proline: Determining substrate selectivity of Dipeptidyl-peptidase 9 Julia CHARL (University of Cologne) Solving the structure of ZmpC, an extracellular metalloproteinase of Streptococcus pneumoniae, using Cryo-EM Kira BICKENBACH (University of Kiel) The metalloprotease meprin β is a sheddase of the transferrin receptor I and influences iron metabolism |
| 2023 | Ulrich ECKHARD Institute of Molecular Biology of Barcelona (IBMB) Xavier GOMIS-RÜTH Institute of Molecular Biology of Barcelona (IBMB) Jan POTEMPA Jagiellonian University | Sam VAN BELJOUW Delft University of Technology Craspase is a CRISPR RNA-guided, RNA-activated protease |
| 2022 | Ulrich ECKHARD Institute of Molecular Biology of Barcelona (IBMB) Evelyn HUTTERER University of Salzburg Walter STÖCKER Johannes Gutenberg University of Mainz | |
| 2021 | Barbara GRÜNWALD University Health Network | |
| 2020 | Ulrich AUF DEM KELLER ETH Zurich Christopher OVERALL University of British Columbia | Alaa ALHAYEK Saarland University & Helmholtz Institute for Pharmaceutical Research Saarland Succinimides as novel pathoblocker agents targeting extracellular bacterial metalloproteases LasB and ColH |
| 2019 | Christoph BECKER-PAULY University of Kiel Stefan ROSE-JOHN Christian-Albrechts-Universität zu Kiel | Stefania WUNDERLI ETH Zurich Proteolytic tendon degeneration after physical unloading heavily depends on the patho-physiological niche |
| 2018 | Lukas MACH University of Natural Resources and Life Sciences, Vienna | Rielana WICHERT University of Kiel Mucus detachment in the small intestine requires shedding of host metalloprotease meprin β, which is abrogated by pathogenic protease RgpB |
2017 | Guy SALVESEN | Jessica GÖTZFRIED |
| 2016 | Ulrich AUF DEM KELLER ETH Zurich | Jennifer VANDOOREN KU Leuven, Rega Institute for Medical Research Novel insights in matrix metalloproteinase-9 trimerization and its functional implications |
| 2015 | Ulrich AUF DEM KELLER ETH Zurich | Pernille SØGAARD University of Oxford DDR1 plays a role in spatial regulation of MT1-MMP activity during epithelial tubulogenesis |
| 2014 | Jim HUNTINGTON University of Cambridge | Elfriede DALL University of Salzburg Structural and mechanistic basis of legumain inhibition by cystatins |
| 2013 | Walter STÖCKER University of Mainz | Claudia BRODER University of Kiel It’s Make or Break: The Metalloproteases Meprin α and Meprin β are C- and N-Procollagenases associated with Ehlers-Danlos syndrome VII |
