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Publications in the field of proprotein-convertase research

Dahms, S. O., Schnapp, G., Winter, M., Buttner, F. H., Schleputz, M., Gnamm, C., Pautsch, A., Brandstetter, H. (2022). Dichlorophenylpyridine-Based Molecules Inhibit Furin through an Induced-Fit Mechanism. ACS Chem Biol, 17(4), 816-821.  doi:10.1021/acschembio.2c00103

Lam van, T. V., Heindl, M. R., Schlutt, C., Bottcher-Friebertshauser, E., Bartenschlager, R., Klebe, G., Brandstetter, H., Dahms, S. O., Steinmetzer, T. (2021). The Basicity Makes the Difference: Improved Canavanine-Derived Inhibitors of the Proprotein Convertase Furin. ACS Med Chem Lett, 12(3), 426-432.  doi:10.1021/acsmedchemlett.0c00651

Dahms, S. O., Haider, T., Klebe, G., Steinmetzer, T., & Brandstetter, H. (2021). OFF-State-Specific Inhibition of the Proprotein Convertase Furin. ACS Chem Biol, 16(9), 1692-1700.  doi:10.1021/acschembio.1c00411

Van Lam van, T., Ivanova, T., Hardes, K., Heindl, M. R., Morty, R. E., Bottcher-Friebertshauser, E., Lindberg, I., Than, M. E., Dahms, S. O., Steinmetzer, T. (2019). Design, Synthesis, and Characterization of Macrocyclic Inhibitors of the Proprotein Convertase Furin. ChemMedChem, 14(6), 673-685.  doi:10.1002/cmdc.201800807

Dahms, S. O., Hardes, K., Steinmetzer, T., & Than, M. E. (2018). X-ray Structures of the Proprotein Convertase Furin Bound with Substrate Analogue Inhibitors Reveal Substrate Specificity Determinants beyond the S4 Pocket. Biochemistry, 57(6), 925-934.  doi:10.1021/acs.biochem.7b01124

Ivanova, T., Hardes, K., Kallis, S., Dahms, S. O., Than, M. E., Kunzel, S., Bottcher-Friebertshauser, E., Lindberg, I., Jiao, G. S., Bartenschlager, R., Steinmetzer, T. (2017). Optimization of Substrate-Analogue Furin Inhibitors. ChemMedChem, 12(23), 1953-1968.  doi:10.1002/cmdc.201700596

Dahms, S. O., Jiao, G. S., & Than, M. E. (2017a). Structural Studies Revealed Active Site Distortions of Human Furin by a Small Molecule Inhibitor. ACS Chem Biol, 12(5), 1211-1216.  doi:10.1021/acschembio.6b01110

Dahms, S. O., Creemers, J. W., Schaub, Y., Bourenkov, G. P., Zogg, T., Brandstetter, H., & Than, M. E. (2016). The structure of a furin-antibody complex explains non-competitive inhibition by steric exclusion of substrate conformers. Sci Rep, 6, 34303.  doi:10.1038/srep34303

Dahms, S. O., Arciniega, M., Steinmetzer, T., Huber, R., & Than, M. E. (2016). Structure of the unliganded form of the proprotein convertase furin suggests activation by a substrate-induced mechanism. Proc Natl Acad Sci U S A, 113(40), 11196-11201.  doi:10.1073/pnas.1613630113

Lu, Y., Hardes, K., Dahms, S. O., Bottcher-Friebertshauser, E., Steinmetzer, T., Than, M. E., Klenk, H. D., Garten, W. (2015). Peptidomimetic furin inhibitor MI-701 in combination with oseltamivir and ribavirin efficiently blocks propagation of highly pathogenic avian influenza viruses and delays high level oseltamivir resistance in MDCK cells. Antiviral Res, 120, 89-100.  doi:10.1016/j.antiviral.2015.05.006

Hardes, K., Becker, G. L., Lu, Y., Dahms, S. O., Kohler, S., Beyer, W., Sandvig, K., Yamamoto, H., Lindberg, I., Walz, L., von Messling, V., Than, M. E., Garten, W., Steinmetzer, T. (2015). Novel Furin Inhibitors with Potent Anti-infectious Activity. ChemMedChem, 10(7), 1218-1231.  doi:10.1002/cmdc.201500103

Fittler, H., Depp, A., Avrutina, O., Dahms, S. O., Than, M. E., Empting, M., & Kolmar, H. (2015). Engineering a Constrained Peptidic Scaffold towards Potent and Selective Furin Inhibitors. Chembiochem, 16(17), 2441-2444.  doi:10.1002/cbic.201500447

Dahms, S. O., Hardes, K., Becker, G. L., Steinmetzer, T., Brandstetter, H., & Than, M. E. (2014). X-ray structures of human furin in complex with competitive inhibitors. ACS Chem Biol, 9(5), 1113-1118.  doi:10.1021/cb500087x