Publications

Int J Mol Sci. 2023 Mar 23;24(7):6101. doi: 10.3390/ijms24076101. Emerging Personalized Opportunities for Enhancing Translational Readthrough in Rare Genetic Diseases and Beyond. Wagner RN, Wießner M, Friedrich A, Zandanell J, Breitenbach-Koller H, Bauer JW.

Skin Pharmacol Physiol 2021 Apr 6;1-16. doi: 10.1159/000513260. Drug Development for Target Ribosomal Protein rpL35/uL29 for Repair of LAMB3R635X in Rare Skin Disease Epidermolysis Bullosa. Rathner A, Rathner P, Friedrich A, Wießnmer M, Kitzler CM, Schernthaner J, Karl T, Krauß J, Lottspeich F, Mewes W, Hintner H, Bauer JW, Breitenbach M, Müller N, Breitenbach-Koller H, von Hagen J

G3 (Bethesda). 2020 Oct 22:g3.401537.2020. doi: 10.1534/g3.120.401537. Online ahead of print. Slow Growth and Increased Spontaneous Mutation Frequency in Respiratory Deficient afo1(-) Yeast Suppressed by a Dominant Mutation in ATP3. Li J, Rinnerthaler M, Hartl J, Weber M, Karl T, Breitenbach-Koller H, Mülleder M, Vowinckel J, Marx H, Sauer M, Mattanovich D, Ata Ö, De S, Greslehner GP, Geltinger F, Burhans B, Grant C, Doronina V, Ralser M, Streubel MK, Grabner C, Jarolim S, Moßhammer C, Gourlay CW, Hasek J, Cullen PJ, Liti G, Ralser M, Breitenbach M.

Am J Reprod Immunol. 2019 May 27:e13152. doi: 10.1111/aji.13152. [Epub ahead of print] Quantitative analysis of the sHLA-G protein in seminal plasma. Schallmoser A, Raab M, Karn T, Königsberger S, Schmidt E, Breitenbach-Koller H, Sänger N.

Eur J Prev Cardiol. 2019 Mar;26(4):348-355. doi: 10.1177/2047487318808014. Exercise responsive micro ribonucleic acids identify patients with coronary artery disease. Mayr B, Müller EE, Schäfer C, Droese S, Breitenbach-Koller H, Schönfelder M, Niebauer J.

Wien Med Wochenschr. 2018 Sep;168(11-12):286-299. doi: 10.1007/s10354-018-0640-4. The defense and signaling role of NADPH oxidases in eukaryotic cells: Review. Breitenbach M, Rinnerthaler M, Weber M, Breitenbach-Koller H, Karl T, Cullen P, Basu S, Haskova D, Hasek

J. Front Oncol. 2017 May 31;7:111. doi: 10.3389/fonc.2017.00111. The Human NADPH Oxidase, Nox4, Regulates Cytoskeletal Organization in Two Cancer Cell Lines, HepG2 and SH-SY5Y. Auer S, Rinnerthaler M, Bischof J, Streubel MK, Breitenbach-Koller H, Geisberger R, Aigner E, Cadamuro J, Richter K, Sopjani M, Haschke-Becher E, Felder TK, Breitenbach M.

Open Biol. 2017 Jan;7(1). pii: 160291. doi: 10.1098/rsob.160291. The control of translational accuracy is a determinant of healthy ageing in yeast.  von der Haar T, Leadsham JE, Sauvadet A, Tarrant D, Adam IS, Saromi K, Laun P, Rinnerthaler M, Breitenbach-Koller H, Breitenbach M, Tuite MF, Gourlay CW.

Hum Mutat. 2015 Dec;36(12):1155-8. Epub 2015 Sep 14. A Novel Mutation in RPL10 (Ribosomal Protein L10) Causes X-Linked Intellectual Disability, Cerebellar Hypoplasia, and Spondylo-Epiphyseal Dysplasia. Zanni G, Kalscheuer VM, Friedrich A, Barresi S, Alfieri P, Di Capua M, Haas SA, Piccini G, Karl T, Klauck SM, Bellacchio E, Emma F, Cappa M, Bertini E, Breitenbach-Koller L.

Biomolecules. 2015 Apr 3;5(2):318-42. Oxidative stress in fungi: its function in signal transduction, interaction with plant hosts, and lignocellulose degradation. Breitenbach M, Weber M, Rinnerthaler M, Karl T, Breitenbach-Koller L

Nat Commun. 2015 Jan 30;6:6158. Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan. Schosserer M, Minois N, Angerer TB, Amring M, Dellago H, Harreither E, Calle-Perez A, Pircher A, Gerstl MP, Pfeifenberger S, Brandl C, Sonntagbauer M, Kriegner A, Linder A, Weinhäusel A, Mohr T, Steiger M, Mattanovich D, Rinnerthaler M, Karl T, Sharma S, Entian KD, Kos M, Breitenbach M, Wilson IB, Polacek N, Grillari-Voglauer R, Breitenbach-Koller L, Grillari

J Mol Autism. 2014 Feb 10;5(1):10. Protein signatures of oxidative stress response in a patient specific cell line model for autism. Chiocchetti AG, Haslinger D, Boesch M, Karl T, Wiemann S, Freitag CM, Poustka F, Scheibe B, Bauer JW, Hintner H, Breitenbach M, Kellermann J, Lottspeich F, Klauck SM, Breitenbach-Koller L

FEMS Yeast Res. 2013 Dec 27. Mitochondria in ageing: there is metabolism beyond the ROS. Breitenbach M, Rinnerthaler M, Hartl J, Stincone A, Vowinckel J, Breitenbach-Koller H, Ralser M.

PLoS One. 2013 Oct 28;8(10). Mmi1, the yeast homologue of mammalian TCTP, associates with stress granules in heat-shocked cells and modulates proteasome activity. Rinnerthaler M, Lejskova R, Grousl T, Stradalova V, Heeren G, Richter K, Breitenbach-Koller L, Malinsky J, Hasek J, Breitenbach M.

PLoS One. 2013 Jul 8;8(7). Specialized Yeast Ribosomes: A Customized Tool for Selective mRNA Translation. Johann W. Bauer, Clemens Brandl, Olaf Haubenreisser, Bjoern Wimmer, Manuela Weber, Thomas Karl, Alfred Klausegger, Michael Breitenbach, Helmut Hintner, Tobias von der Haar, Mick F. Tuite, Lore Breitenbach-Koller

Proc Natl Acad Sci U S A. 2012 May 14. [Epub ahead of print]. Yno1p/Aim14p, a NADPH-oxidase orthologue controls extramitochondrial ROS generation, apoptosis, and actin cable formation in yeast. Rinnerthaler M, Büttner S, Laun P, Heeren G, Felder TK, Klinger H, Weinberger M, Stolze K, Grousl T, Hasek J, Benada O, Frydlova I, Klocker A, Simon-Nobbe B, Jansko B, Breitenbach-Koller H, Eisenberg T, Gourlay CW, Madeo F, Burhans WC, Breitenbach M.

Subcell Biochem. 2012 57:55-78. The role of mitochondria in the aging processes of yeast. Breitenbach M, Laun P, Dickinson JR, Klocker A, Rinnerthaler M, Dawes IW, Aung-Htut MT, Breitenbach-Koller L, Caballero A, Nyström T, Büttner S, Eisenberg T, Madeo F, Ralser M.

Aging. 2009 1:622-636. The mitochondrial ribosomal protein of the large subunit, Afo1p, determines cellular longevity through mitochondrial back-signaling via TOR1. Heeren G, Rinnerthaler M, Laun P, von Seyerl P, Kössler S, Klinger H, Jarolim S, Simon-Nobbe B, Hager M, Schüller C, Carmona-Gutierrez D, Breitenbach-Koller L, Mück C, Jansen-Dürr P, Criollo A, Kroemer G, Madeo F, Breitenbach M.

Biochim Biophys Acta. 2008 1783:1328-34. Senescence and apoptosis in yeast mother cell-specific aging and in higher cells: A short review. Laun P, Heeren G, Rinnerthaler M, Rid R, Kössler S, Koller L, Breitenbach M.

Exp Gerontol. 2007 42:275-86. Ribosomal proteins Rpl10 and Rps6 are potent regulators of yeast replicative life span. Chiocchetti A, Zhou J, Zhu H, Karl T, Haubenreisser O, Rinnerthaler M, Heeren G, Oender K, Bauer J, Hintner H, Breitenbach M, Breitenbach-Koller L.

Mol Psychiatry. 2006 11:1073-84. Mutations in the ribosomal protein gene RPL10 suggest a novel modulating disease mechanism for autism. Klauck SM, Felder B, Kolb-Kokocinski A, Schuster C, Chiocchetti A, Schupp I, Wellenreuther R, Schmötzer G, Poustka F, Breitenbach-Koller L, Poustka A.

Biochim Biophys Acta. 2006 1757:631-638. MMI1 (YKL056c, TMA19), the yeast orthologue of the translationally controlled tumor protein (TCTP) has apoptotic functions and interacts with both microtubules and mitochondria. Rinnerthaler M, Jarolim S, Heeren G, Palle E, Perju S, Klinger H, Bogengruber E, Madeo F, Braun RJ, Breitenbach-Koller L, Breitenbach M, Laun P.

FEMS Yeast Res. 2004 5:271-80. Functional interaction in establishment of ribosomal integrity between small subunit protein rpS6 and translational regulator rpL10/Grc5p. Pachler K, Karl T, Kolmann K, Mehlmer N, Eder M, Loeffler M, Oender K, Hochleitner EO, Lottspeich F, Bresgen N, Richter K, Breitenbach M, Koller L

Yeast 2003 20:281-294. Translational regulator RpL10p/Grc5p interacts physically and functionally with Sed1p, a dynamic component of the yeast cell surface. Önder K, Löffler M, Doppler E, Eder M, Lach S, Heinrich F, Karl T, Mösl R, Hundsberger H, Klade T, Eckl P, Dickinson JR, Breitenbach M, Koller HT

FEMS Yeast Research 2003 3:35-43. Functional analysis in yeast of the Brix protein superfamily involved in the biogenesis of ribosomes. Bogengruber E, Briza P, Doppler E, Wimmer H, Koller L, Fasiolo F, Senger B, Hegemann JH, Breitenbach M

Current Genetics 1999 34:419-29. GRC5 and NMD3 function in translational control of gene expression and interact genetically. Karl T, Önder K, Kodzius R, Pichova A, Wimmer H, Thür A, Hundsberger H, Loffler M, Klade T, Beyer A, Breitenbach M, Koller HT

Yeast 1996 12:53-65. The yeast growth control gene GRC5 is highly homologous to the mammalian putative tumor suppressor gene QM. Koller HT, Klade T, Ellinger A, Breitenbach M